Publications

2017

I Bozic, MA Nowak (2017) Resisting resistance. Annual Review of Cancer Biology 1, 203-221.

JG Reiter, AP Makohon-Moore, JM Gerold, I Bozic, K Chatterjee, CA Iacobuzio-Donahue, B Vogelstein, MA Nowak (2017) Reconstructing robust phylogenies of metastatic cancers. Nature Communications 8, 14114.

AP Makohon-Moore, M Zhang, JG Reiter, I Bozic, B Allen, D Kundu, K Chatterjee, F Wong, Y Jiao, LD Wood, RH Hruban, MA Nowak, N Papadopoulos, KW Kinzler, B Vogelstein, CA Iacobuzio-Donahue (2017) The natural history of pancreatic cancer metastasis is dominated by driver gene homogeneity. Nature Genetics 49, 358-366.

2016

Y Yamamoto, CP Offord, G Kimura, S Kuribayashi, H Takeda, S Tsuchiya, H Shimojo, H Kanno, I Bozic, MA Nowak, Ž Bajzer, D Dingli (2016) Tumor and immune cell dynamics explain the PSA bounce after prostate cancer brachytherapy. British Journal of Cancer 115, 195-202.

JA Burger*, DA Landau*, AN Taylor-Weiner*, I Bozic*, H Zhang*, K Sarosiek, L Wang, C Stewart, J Fan, J Hoellenriegel, M Sivina, AM Dubuc, C Fraser, Y Han, S Li, KJ Livak, L Zou, YWan, S Konoplev, C Sougnez, LV Abruzzo, SL Carter, MJ Keating, MS Davids, WG Wierda, K Cibulskis, T Zenz, L Werner, P Dal Cin, P Kharchencko, D Neuberg, H Kantarjian, E Lander, S Gabriel, S O’Brien, A Letai, DA Weitz, MA Nowak, G Getz, CJ Wu (2016) Clonal evolution in patients with chronic lymphocytic leukemia developing resistance to BTK inhibition. Nature Communications 7, 11589.

I Bozic, JM Gerold, MA Nowak (2016) Quantifying clonal and subclonal passenger mutations in cancer evolution. PLOS Computational Biology 12, e1004731. PDF

2015

DA Landau, E Tausch, AN Taylor-Weiner, C Stewart, JG Reiter, J Bahlo, S Kluth, I Bozic, M Lawrence, S Bottcher, SL Carter, K Cibulskis, D Mertens, C Sougnez, M Rosenberg, JM Hess, J Edelmann, S Kless, M Kneba, M Ritgen, A Fink, K Fischer, S Gabriel, E Lander, MA Nowak, H Dohner, M Hallek, D Neuberg, G Getz, S Stilgenbauer, CJ Wu (2015) Mutations driving CLL and their evolution in progression and relapse. Nature 526, 525-530.

S Misale*, I Bozic*, JS Tong, A Peraza-Penton, A Lallo, F Baldi, K Lin, M Truini, L Trusolino, A Bertotti, F Di Nicolantonio, MA Nowak, L Zhang, K Wood, A Bardelli (2015) Vertical suppression of the EGFR pathway prevents onset of resistance in colorectal cancers. Nature Communications 6, 8305.

B Waclaw, I Bozic, ME Pittman, RH Hruban, B Vogelstein, MA Nowak (2015) A spatial model predicts that dispersal and cell turnover limit intratumour heterogeneity. Nature 525, 261-264.

harvard_gazette_sl  l24930-wired-magazine-logo-50380  inthenews-nature

C Tomasetti, I Bozic (2015) The (not so) immortal strand hypothesis. Stem Cell Research 14, 238-241.

2014

I Bozic, MA Nowak (2014) Timing and heterogeneity of mutations associated with drug resistance in metastatic cancers. Proceedings of the National Academy of Sciences 111, 15964-15968.  PDF

logo-pnas-300x300

2013

I Bozic, MA Nowak (2013) Unwanted evolution. Science 342, 938-939.

I Bozic*, JG Reiter*, B Allen*, T Antal, K Chatterjee, P Shah, YS Moon, A Yaqubie, N Kelly, DT Le, EJ Lipson, PB Chapman, LA Diaz Jr, B Vogelstein, MA Nowak (2013) Evolutionary dynamics of cancer in response to targeted combination therapy. eLife 2, e00747.  PDF  Mathematical Proofs

inthenews-nature  inthenews-boston-globe_8 (1)  harvard_gazette_sl  logo-voa-140-blue2  nytimes-logo-300x300

JG Reiter, I Bozic, K Chatterjee, MA Nowak (2013) TTP: Tool for tumor progression. In Proceedings of 25th International Conference on Computer Aided Verification, Lecture Notes in Computer Science 8044, 101-106.

JG Reiter*, I Bozic*, B Allen, K Chatterjee, MA Nowak (2013) The effect of one additional driver mutation on tumor progression. Evolutionary Applications 6, 34-45.

2012

LA Diaz Jr, R Williams, J Wu, J R Hecht, J Berlin, B Allen, I Bozic, JG Reiter, MA Nowak, KW Kinzler, KS Oliner, B Vogelstein (2012) The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers. Nature 486, 537-540.

DC26492LOGO-300x300  JHM_sl  harvard_gazette_sl  telegraph_s2l  inthenews-nature

I Bozic, B Allen, MA Nowak (2012) Dynamics of targeted cancer therapy. Trends in Molecular Medicine 18, 311-316.  PDF  Mathematical Proofs

2010

S Yachida, S Jones, I Bozic, T Antal, R Leary, B Fu, M Kamiyama, RH Hruban, JR Eshleman, MA Nowak, VE Velculescu, KW Kinzler, B Vogelstein, CA Iacobuzio-Donahue (2010) Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature 467, 1114-1117.

nytimes-logo-300x300  inthenews-nature  bbc_news-300x300  4744.Reuters-Logo

I Bozic, T Antal, H Ohtsuki, H Carter, D Kim, S Chen, R Karchin, KW Kinzler, B Vogelstein, MA Nowak (2010) Accumulation of driver and passenger mutations during tumor progression. Proceedings of the National Academy of Sciences 107, 18545-18550.

logo-pnas-300x300  harvard_gazette_sl  jnci

2009 and before

I Bozic, Z Petrovic (2009) Zero-divisor graphs of matrices over commutative rings. Communications in Algebra 37, 1186-1192.

GL Zhang, I Bozic, CK Kwoh, JT August, V Brusic (2007) Prediction of supertype-specific HLA class I binding peptides using support vector machines.  Journal of Immunological Methods 320, 143-154.

I Bozic, GL Zhang, V Brusic (2005) Predictive vaccinology: optimization of predictions using support vector machine classifiers. In Proceedings of the 6th International Conference on Intelligent Data Engineering and Automated Learning, Lecture Notes in Computer Science 3578, 375-381.

* joint first authors